Immunopathogenesis of HIV/SIV infection in lymph nodes

Version imprimable
November 10, 2017
Richard A. Koup

On November 17th, 2017, the CRCHUM Conferences invites Richard Koup, Chief, Immunology Laboratory and Deputy Director, Vaccine Research Center. During this conference he will discuss the impact of HIV and SIV on the location, dynamics, and function of TFH cells, CD8 T cells, and B cells. 

Abstract

Lymph nodes have complex structures that are necessary for the coordinated development of T and B cell immune responses. They are also the predominant site of HIV and SIV replication in vivo. Follicular CD4 T helper (TFH) cells promote the survival, isotype switching and selection of high affinity memory B cells and plasma cells. Using multiparameter flow cytometry, confocal imaging, and RNA expression profiling, we investigated the impact of HIV and SIV on the location, dynamics, and function of TFH cells, CD8 T cells, and B cells. A better understanding of virus/host interactions within lymph nodes may lead to better approaches to vaccine and therapeutic strategies.

This conference will be presented in English.

Friday, November 17th, 2017, at Noon.
Auditorium of the CRCHUM, R05.210 and R05.220
900 Saint-Denis Street, 5th floor
Montreal (Quebec)  H2X 0A9

Richard Koup, MD
Chief, Immunology Laboratory
Deputy Director,
Vaccine Research Center, NIAID, NIH 

 

About CRCHUM Conferences

The CRCHUM Conferences are free weekly meetings featuring renowned scientific speakers from various disciplines. These conferences are accredited by the Royal College of Physicians and Surgeons of Canada as continuing professional development activities. The CRCHUM conferences are made possible thanks to the financial support of our partners: AstraZeneca, Biron, Charles River, GSK Canada, Lilly, Médicaments novateurs Canada, Merck, Pfizer, Québecor, Roche & Servier.

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