Human and animal neuroimmunology (mouse models), auto-immunity, multiple sclerosis, T and B lymphocytes, central nervous system, cytokines, in vitro immunological studies, tissue cultures, flow cytometry, cell and molecular biology.
Neuroimmunology : interactions between two complex systems : the immune system and the central nervous system (brain and spinal cord).
Elucidation of the mechanisms whereby T lymphocytes (CD8 and CD4) attack cells of the central nervous system and thus contribute to the pathogenesis of autoimmune diseases such as multiple sclerosis.
Characterization of molecules (ligands, cytokines, intracellular proteins) expressed by the central nervous system to locally modulate immune responses.
Impact of cytokines on the functions of cells of the immune system and the central nervous system.
CIHR-supported training program in neuroinflammation (www.neuroinflammation.com)