Molecular biology, DNA repair, DNA damage response signaling, DNA damage adaptation, cellular senescence, aging, cancer.
The laboratory focuses it’s research on identifying cellular and tissue mediators of the mammalian DNA damage response. This important biological phenomenon is involved in human aging, cancer development, and influences the outcome of cancer therapy.
More specifically, we want to understand how the DNA damage response is terminated following DNA lesion repair, and how cancer cells can often tolerate persistent DNA damage signalling that occurs when DNA lesions are irreparable. To achieve these goals, we combine cell culture and animal/human models with cutting edge scientific tools. In collaboration with clinicians, we are also working to develop new molecular diagnostic tools for cancer detection and we are trying to identify cellular targets to sensitize cancer cells to chemotherapy or radiotherapy.